The Metabolomix+ is a unique combination of nutritional tests that provides an analysis of key nutritional biomarkers. Metabolomix+ nutritional test is a non-invasive, patient-friendly way to assess the functional need for antioxidants, B-vitamins, minerals, digestive support,  amino acids urine elements (add-on) and fatty acids (add-on).

Metabolomix+ Test Covers

• Organic Acids
• Malabsorption and Dysbiosis
• Cellular Energy and Mitochondrial Metabolites
• Neurotransmitter Metabolites
• Vitamin Markers
• Toxin and Detoxification Markers
• Tyrosine Metabolism
• New! Oxalate markers
• Amino Acids
• Nutritionally Essential Amino Acids
• Nonessential Protein Amino Acids
• Intermediary Metabolites
• Dietary Peptide Related Markers
• Oxidative Stress Markers
• Essential and Metabolic Fatty Acids - Bloodspot (if selected as add-on profile)
• Omega 3 Fatty Acids
• Omega 6 Fatty Acids
• Omega 9 Fatty Acids
• Saturated Fatty Acids
• Monounsaturated Fatty Acids
• Delta-6 Desaturase Activity
• Cardiovascular Risk
• Nutrient and Toxic Elements (if selected as add-on profile)
• 4 SNPs for nutritional status (if selected as add-on profile)

Overview

Common clinical indications for testing include:

• Mood Disorders
• Mitochondrial Dysfunction
• Fatigue
• Chronic Stress
• Inflammation

Several diseases are associated with abnormal organic acid, amino acid, and fatty acid levels such as depression, anxiety, cardiovascular disease, neurocognitive decline, diabetes, cancer, anorexia, and many others.

Analytes tested: 
1-Methylhistidine
2-Hydroxyphenylacetic Acid
3-Hydroxyproprionic Acid
3-Methyl-4-OH-phenylglycol
3-Methylhistidine
4-Hydroxyphenylpyruvic Acid
5-OH-Indoleacetic Acid
8-OHdG
APOE (Add-on)
Adipic Acid
Alanine
Alpha-amino-N-butyric acid
Alpha-aminoadipic acid
Aluminum (Add-on)
Anserine (dipeptide)
Antimony (Add-on)
Arabinose
Arachidic (Add-on)
Arachidonic (Add-on)
Arginine
Arsenic (Add-on)
Asparagine
Aspartic acid
Barium (Add-on)
Behenic (Add-on)
Benzoic
Benzoic/Hippuric Acids Ratio
Beta-alanine
Beta-aminoisobutyric acid
Bismuth (Add-on)
COMT (V158M) (Add-on)
Cadmium (Add-on)
Calcium (Add-on)
Carnosine (dipeptide)
Cesium (Add-on)
Chromium (Add-on)
Cis-Aconitic Acid
Citramalic Acid
Citric Acid
Citrulline
Cobalt (Add-on)
Copper (Add-on)
Creatinine
Creatinine (Add-on)
Cystathionine
Cysteine
Cystine
Dihomo-gamma-linolenic (Add-on)
Dihydroxyphenylpropionic Acid
Docosahexaenoic (Add-on)
Docosapentaenoic (Add-on)
Docosatetraenoic (Add-on)
Eicosadienoic (Add-on)
Eicosapentaenoic (Add-on)
Elaidic (Add-on)
Ethanolamine
Formiminoglutamic Acid (FIGlu)
Gadolinium (Add-on)
Gallium (Add-on)
Gamma-Linolenic (Add-on)
Gamma-aminobutyric acid
Glucose
Glutamic acid
Glutamine
Glutaric Acid
GlycineGlyceric Acid
Glycolic Acid
Gondoic (Add-on)
Hippuric
Histidine
Homogentisic Acid
Homovanillic Acid
Indoleacetic Acid
Iron (Add-on)
Isocitric Acid
Isoleucine
Kynurenic Acid
Lactic Acid
Lead (Add-on)
Leucine
Lignoceric (Add-on)
Linoleic (Add-on)
Lipid Peroxides
Lithium (Add-on)
Lysine
MTHFR (C677T and A1298C) (Add-on)
Magnesium (Add-on)
Malic Acid
Manganese (Add-on)
Margaric (Add-on)
Mercury (Add-on)
Methionine
Methylmalonic Acid
Molybdenum (Add-on)
Nervonic (Add-on)
Nickel (Add-on)
Niobium (Add-on)
Oleic (Add-on)
Ornithine
Orotic Acid

Oxalic Acid
Palmitic (Add-on)
Palmitoleic (Add-on)
Pentadecanoic (Add-on)
Phenylacetic Acid
Phenylalanine
Phosphoethanolamine
Phosphoserine
Platinum (Add-on)
Proline
Pyroglutamic Acid
Pyruvic Acid
Rubidium (Add-on)
Sarcosine
Selenium (Add-on)
Serine
Stearic (Add-on)
Strontium (Add-on)
Suberic Acid
Succinic Acid
Sulfur (Add-on)
TNF-a (Add-on)
Taurine
Thallium (Add-on)
Thorium (Add-on)
Threonine
Tin (Add-on)
Tricosanoic (Add-on)
Tryptophan
Tungsten (Add-on)
Tyrosine
Uranium (Add-on)
Urea
Vaccenic (Add-on)
Valine
Vanadium (Add-on)
Vanilmandelic Acid
Zinc (Add-on)
a-Keto-b-Methylvaleric Acid
a-Ketoadipic Acid
a-Ketoglutaric Acid
a-Ketoisocaproic Acid
a-Ketoisovaleric Acid
alpha-Linolenic (Add-on)
b-OH-Butyric Acid
b-OH-b-Methylglutaric Acid

Practical

Sample required:

Urine - FMV

Available add-ons:

• Fatty acids add-on for Metabolomix+
• Urine elements add-on for Metabolomix+
• Vitamin D add-on for Metabolomix+

Research

1. Kaluzna-Czaplinska J. Noninvasive urinary organic acids test to assess biochemical and nutritional individuality in autistic children. Clin Biochem. 2011;44(8-9):686-691.
2. Broquist HP, Luhby AL. Detection and isolation of formiminoglutamic acid from urine in folic acid deficiency in humans. Proc Soc Exp Biol Med. 1959;100(2):349-354.
3. Sun A-l, Ni Y-h, Li X-b, et al. Urinary methylmalonic acid as an indicator of early vitamin B12 deficiency and its role in polyneuropathy in type 2 diabetes. J Diab Res. 2014;2014.
4. Kwok T, Cheng G, Lai W, Poon P, Woo J, Pang C. Use of fasting urinary methylmalonic acid to screen for metabolic vitamin B12 deficiency in older persons. Nutrition. 2004;20(9):764-768.
5. Brown R, Thornton MJ, Price J. The effect of vitamin supplementation on the urinary excretion of tryptophan metabolites by pregnant women. J Clin Invest. 1961;40(4):617-623.
6. Lykouras L, Markianos M, Hatzimanolis J, Malliaras D, Stefanis C. Association of biogenic amine metabolites with symptomatology in delusional (psychotic) and nondelusional depressed patients. Prog Neuro-Psychopharmacol Biol Psych. 1995;19(5):877-887.
7. Frankenhaeuser M, Lundberg U, Von Wright MR, Von Wright J, Sedvall G. Urinary monoamine metabolites as indices of mental stress in healthy males and females. Pharmacol Biochem Behav. 1986;24(6):1521-1525.
8. Mitochondrial Medicine Society's Committee on D, Haas RH, Parikh S, et al. The in-depth evaluation of suspected mitochondrial disease. Mol Genet Metab. 2008;94(1):16-37.
9. Dimmock DP, Lawlor MW. Presentation and Diagnostic Evaluation of Mitochondrial Disease. Pediatr Clin North Am. 2017;64(1):161-171.
10. Wu H, Jiang K, Gu G, Wu Y, Yu S. [The relationship of occupational stress and the level of some hormone metabolites in urine]. Chin J Indust Hyg Occup Dis. 2014;32(2):83-86.
11. Jeon SW, Kim Y-K. Inflammation-induced depression: Its pathophysiology and therapeutic implications. J Neuroimmunol. 2017;313:92-98.
12. Rao TSS, Asha MR, Ramesh BN, Rao KSJ. Understanding nutrition, depression and mental illnesses. Indian J Psychiatry. 2008;50(2):77-82.
13. O'Connell BS. Select vitamins and minerals in the management of diabetes. Diabetes Spectr. 2001;14(3):133-148.
14. Harris WS. Omega-3 fatty acids and cardiovascular disease: a case for omega-3 index as a new risk factor. Pharmacol Res. 2007;55(3):217-223.
15. Spencer SJ, Korosi A, Layé S, Shukitt-Hale B, Barrientos RM. Food for thought: how nutrition impacts cognition and emotion. Sci Food. 2017;1(1):1-8.